Case of the Month | December 2023

Case of the Month
December 25, 2023

The Case

The patient was a 64 year old white man who complained of “kaleidoscope” episodes lasting 5-20 minutes in the right eye for two years. The episodes had increased in frequency such that there was one or more daily when he saw us. He said that stress and bright lights seemed to increase his symptoms. He had been in good general health and had no other significant ocular history. He said that he sometimes had headaches associated with the episodes but not at other times. He had been in good general health and had no systemic complaints.

The visual acuity was 20/20-2 OD and 20/20-1 OS. Eye pressures were normal. The anterior segment examination was remarkable for a mild nuclear sclerotic cataract in each eye. Both optic nerves and maculas looked good. There were peripheral intraretinal hemorrhages in the right eye. The OCT of the right eye showed mild edema. The OCTA and autofluorescence of each eye were unremarkable. The fluorescein angiogram of the right eye revealed normal filling times, mild temporal peripheral ischemia with staining of peripheral blood vessels. There was late perifoveal leakage without disc leakage. The FA of the left eye was unremarkable. What are the diagnostic considerations? What further evaluation would you recommend?

The most common cause of peripheral retinal hemorrhages is ocular ischemic syndrome, which is usually due to carotid occlusive disease. Our patient was found on carotid ultrasonography to have a total occlusion of the right internal carotid artery. There was also significant stenosis of the left internal carotid artery. While carotid endarterectomy is not helpful in the setting of total occlusion, it can be indicated in patients with significant stenosis. Our patient had left carotid endarterectomy and has been doing well. He was also found to have coronary artery disease, and he had a stent placed.

There are many diagnostic considerations in patients with peripheral intraretinal hemorrhages. Diabetic retinopathy, hypertensive retinopathy, and leukemia generally have hemorrhages in the posterior pole as well as the periphery. Autoimmune conditions such as lupus erythematosus or Eales’ disease is another consideration. While there was some capillary nonperfusion in the temporal periphery of the right eye, there was no occlusion of larger retinal blood vessels and there was no disc leakage. Familial exudative vitreoretinopathy is usually bilateral, and there is typically incomplete vascularization of the peripheral retina. Our patient’s work-up included CBC, fasting glucose, sed rate, and C-reactive protein, all of which were unremarkable.

Case Photos

Click the Images below to enlarge
Photo OD
Photo OS
OCT OD
OCT OS
FA OD 0:36
OCT OD 1:02
FA OD 2:57
FA OD 5:49
FA OS 1:19
FA OS 4:31

The most common cause of peripheral retinal hemorrhages is ocular ischemic syndrome, which is usually due to carotid occlusive disease. Our patient was found on carotid ultrasonography to have a total occlusion of the right internal carotid artery. There was also significant stenosis of the left internal carotid artery. While carotid endarterectomy is not helpful in the setting of total occlusion, it can be indicated in patients with significant stenosis. Our patient had left carotid endarterectomy and has been doing well. He was also found to have coronary artery disease, and he had a stent placed.

There are many diagnostic considerations in patients with peripheral intraretinal hemorrhages. Diabetic retinopathy, hypertensive retinopathy, and leukemia generally have hemorrhages in the posterior pole as well as the periphery. Autoimmune conditions such as lupus erythematosus or Eales’ disease is another consideration. While there was some capillary nonperfusion in the temporal periphery of the right eye, there was no occlusion of larger retinal blood vessels and there was no disc leakage. Familial exudative vitreoretinopathy is usually bilateral, and there is typically incomplete vascularization of the peripheral retina. Our patient’s work-up included CBC, fasting glucose, sed rate, and C-reactive protein, all of which were unremarkable.

AREDS Study
Return to News & Events